Endocrine Abstracts

Background: Clinical reactive hypoglycemic events are defined as the coexistence of plasma glucose <60 mg/dl and autonomic and/or neuroglycopenic symptoms occurring in fed conditions. The diagnosis is based on tests aiming to simulate the causative triggers (i.e. mixed meal test). In clinical practice, however, a high percentage of symptomatic patients results negative to such diagnostic approach, leading to the impression of an inadequate sensitivity of this diagnostic to...

Background and aims: Alterations of mood and depression may be associated with type 2 diabetes (T2DM) and impaired glucose metabolism in non-diabetic people. Central serotoninergic activity may modulate glucose tolerance via neuroendocrine effectors. The serotoninergic tone was assessed by measuring the hormonal response to a selective serotonin reuptake inhibitor, citalopram, in non-diabetic subjects and patients with T2DM followed by either a traditional approach or a clinic...